DIM - A Natural Approach To Oestrogen Management

DIM (Diindolylmethane), discovered in cruciferous vegetables, is a natural indole which promotes beneficial oestrogen metabolism in both women and men.

BioResponse DIM^® supports cytochrome enzyme activity, increasing production of 'good' oestrogen metabolites while reducing harmful metabolites.

Prominent researchers have documented that this balance is an important factor in maintaining breast, uterine, cervical and prostate health. Women and men also use BioResponse DIM^® as an integral part of successful weight management programs.

How DIM Works

When included as a dietary ingredient, BioResponse DIM^® use supports metabolism and augments our dietary intake of cruciferous vegetables. A daily intake of 3-5 servings of vegetables, especially cruciferous vegetables, is recommended by the USDA "Dietary Guidelines for Americans". BioResponse DIM^® provides a source of cruciferous indole which is shelf-stable following mixture, encapsulation or tableting with other dietary supplement ingredients. Regular use of BioResponse DIM^® serves to augment or replace deficient daily intake of cruciferous vegetables, contributing to health promotion.

How Is BioResponse DIM Unique?

• BioResponse DIM^® promotes a more favourable metabolism of oestrogen.
• Unlike I3C (Indole-3-carbinol), DIM released from BioResponse DIM^® requires no action by stomach acid to be active as a support for metabolism.
• BioResponse DIM^® promotes the production of 2 hydroxyestrone and 2-methoxyestrone, key metabolites in men and women.
• BioResponse DIM^® provides proven bioavailability of highly insoluble active DIM through action of its patented dosage form and delivery system.

The Importance Of Bioavability

To be beneficial, pure DIM needs to be made bioavailable (absorbable). This hurdle was cleared in 1998 when BioResponse Nutrients developed its unique and patented delivery system - the only method known to produce truly absorbable DIM. BioResponse Diindolylmethane is the first and only DIM in a patented delivery system that provides predictable absorption.

BioResponse DIM^® acts to overcome the extreme insolubility of DIM and makes DIM absorbable from the human digestive tract. The absorption-enhancing formulation is a patented, nutrient delivery system necessary for adequate absorption of pure DIM. Once absorbed, DIM from BioResponse DIM^® acts to promote and support a favorable metabolism of estrogen and related hormones.

BioResponse DIM^® contains pure DIM, microencapsulated in particles complexed with a vitamin E derivative and phospholipids to allow absorption from our intestinal track. The patented formulation process for making BioResponse DIM^® creates microparticles of DIM, emulsifies the DIM with vitamin E and phospholipids and captures these complexes through a drying process in larger particles of pure food starch. This results in a sustained-release, dry powder which re-dissolves easily after oral consumption.

Learn more about BioResponse DIM^®  absorption...

BioResponse DIM^® is the only DIM with proven absorption and activity demonstrated in independently performed clinical studies. BioResponse's patented formulation contains microencapsulated complexes of diindolylmethane for guaranteed and sustained gastrointestinal absorption. This patented technology is the only formulation of DIM with an awarded US Patent #6,086,915.

Learn more about BioResponse DIM^® vs I3C...

Learn more about BioResponse DIM^® vs Generic DIM...

Radiance^® DIM^® contains the one and only patented BioResponse DIM^®, a dietary supplement contains:
75mg BioResponse DIM^® Complex (patented, enhanced bioavailability diindolylmethane complex)

100% vegetarian product.  Vegetable cellulose capsule. Corn starch, vitamin E (as natural d-alpha tocopheryl succinate), soy phosphatidyl choline, silica. 

Radiance^® DIM^® is free of yeast, artificial coloring, or preservatives.

BioResponse DIM^® is the dietary ingredient of choice, backed by scientific studies. 

Healthy oestrogen metabolism, breast, uterine, cervical, and prostate health are all under clinical study using BioResponse’s microencapsulated absorbable DIM^® at numerous universities worldwide.

Learn more about the advantages of BioResponse DIM^®...

Learn more about BioResponse DIM^® research. . .

Michael A. Zeligs, M.D.

Michael A. Zeligs, M.D., is the Founder and CEO of BioResponse Nutrients and the co-inventor of patented, microencapsulated Diindolylmethane (BioResponse DIM^®). Dr. Zeligs was the first to discover novel nutritional approaches with cruciferous DIM, and has numerous patents for uses of DIM including hormonal health, breast health, and weight loss.

Dr. Zeligs earned a Masters degree in stress-physiology from the University of California, Santa Barbara, and a M.D. degree from the University of California, Irvine, College of Medicine. As a physician-investigator, he has sponsored numerous clinical trials using microencapsulated BioResponse DIM^®.

Dr. Zeligs supports clinical trials that are underway using BioResponse DIM^® in collaboration with Cornell University, the NYU School of Medicine, Cancer Research UK, Wayne State University, and New York Medical College. BioResponse Nutrients works with the National Cancer Institute (NCI) under a clinical trials agreement to discover the further health potential of DIM.